Promethazine Symptoms and indicators of overdosage with promethazine HCI range from gentle melancholy on the central anxious program and cardiovascular method to profound hypotension, respiratory despair, unconsciousness, and unexpected Loss of life.
Promethazine is effectively absorbed from the gastrointestinal tract. Medical results are clear in just twenty minutes following oral administration and customarily previous 4 to six several hours, Despite the fact that They could persist provided that 12 hours.
It is freely soluble in h2o and Liquor. Phenylephrine hydrochloride is subject to oxidation and has to be shielded from gentle and air. It's got a molecular bodyweight of 203.sixty seven, a molecular system of C9H13NO2 • HCl, and the following structural system:
Akorn lean refers back to the misuse of Akorn promethazine-codeine syrup in lean beverages. People combine the syrup with soda and candy to create a sweet, sedative beverage.
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Distinct studies to test the motion of the drug on parturition, lactation, and growth of the animal neonate were not performed, but a common preliminary review in rats indicated no effect on these parameters.
WARNING: Maintain this and all medicine out on the access of kids. In case of accidental overdose, request Qualified support or Make contact with a poison control Heart right away.
Phenylephrine with bronchodilator sympathomimetic brokers and with epinephrine or other sympathomimetics.
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Phenylephrine ought to be applied with caution in sufferers having diet regime Akorn syrub preparations, such as amphetamines or phenylpropanolamine, due to the fact synergistic adrenergic effects could cause major hypertensive response and attainable stroke.
Phenylephrine really should not be used in patients acknowledged to be hypersensitive to your drug or in These acquiring a monoamine oxidase inhibitor (MAOI).
Because of the hazards of habit, abuse, and misuse with opioids, even at proposed doses [see Warnings and Safety measures (five.one)], reserve promethazine HCl and codeine phosphate oral Answer for use in adult individuals for whom the many benefits of cough suppression are expected to outweigh the dangers, and in whom an sufficient assessment from the etiology in the cough has actually been designed.
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